Kidney disease is among the most uncomfortable conditions that are relatively expensive to treat. Kidneys signify a major organ system of cardiovascular function as well as waste excretion. Accordingly, factors affecting kidney function may indirectly impact different physiological processes, like blood pressure regulation, sodium excretion, heart rate and retention of salt and water balance within the body. Glomerulonephritis is commonly referred to by doctors for a group of diseases where damage to the glomeruli results from the body’s immune or natural defense system. It leads to swelling of body tissue (edema), the presence of red blood cells in the urine, and high blood pressure. CBD aids with glomerulonephritis by lowering inflammation, managing high blood pressure and improving kidney function.
What Constitutes Glomerulonephritis?
Glomerulonephritis signifies a variety of inflammatory kidney conditions of the small blood vessels in the kidneys, called glomeruli. It may be acute, which implies it begins suddenly, or chronic, which leads to gradual onset. Either type can be deadly.
The glomeruli function as small filters in the kidneys. Each kidney possesses millions of glomeruli.
If the glomeruli get damaged, the kidneys can no longer eliminate waste and excess fluids effectively. Protein and blood cannot be filtered and are discharged in the urine.
Primary glomerulonephritis signifies the occurrence of glomerulonephritis in the absence of an accompanying condition, whereas secondary glomerulonephritis results from another disease, like diabetes, drug use, or infection.
Causes Of Glomerulonephritis
There are several causes of Glomerulonephritis. Common causes comprise HIV, lupus, and Hepatitis B or C. The trigger for many instances is unknown but is believed to be linked to something that makes the immune system to attack the kidneys. A few instances of glomerulonephritis tend to go down in families and carry a genetic cause.
Symptoms Of Glomerulonephritis
Nearly half of the people with acute glomerulonephritis possess no symptoms. If symptoms do happen, the initial to appear is tissue swelling (edema) on account of fluid retention, decreased volume of urine, and production of dark urine as it contains blood. Edema may initially appear as puffiness in the face and eyelids but later gets prominent in the legs. Blood pressure rises as kidney function gets impaired. Few people get drowsy or confused. In aged people, nonspecific symptoms, like nausea and a general feeling of illness (malaise), are more common.
When rapidly advancing glomerulonephritis happens, weakness, fever, and fatigue are the most common early symptoms. Absence of appetite, vomiting, abdominal pain, nausea, and joint pain are also prevalent. Nearly half of people possess a flu-like illness in the month prior to the development of kidney failure. These people carry edema and generally produce very little urine.
How Does CBD Help With Glomerulonephritis
A person suffering from kidney disease does not filter metabolic wastes, extra minerals, and fluids from the blood correctly. Glomerulonephritis damages glomeruli rendering the kidney unable to perform its functions. CBD has indicated potential to alleviate most of the symptoms of glomerulonephritis.
Aids To Fight Inflammation
CBD blocks the inflammatory cytokines that impact the kidney negatively. CBD also lowers cytokines activity along their pathway. This activity promotes the expression of genes that lead to inflammation. Thereby CBD prevents damage to the glomeruli and the kidney.
Factors that cause kidney inflammation comprise bacterial infection and exposure to toxicity (FDA-approved drugs, heavy metals, etc). CBD may modify kidney function in an indirect manner by reducing inflammation. Stimulation of CB2 receptors produces an anti-inflammatory impact, leading to a lessening of infiltration of inflammatory cell and lowering cytokines production (a molecule which raises inflammation). In another research employing acute kidney injury of a mouse model, activation of the CB1 receptor is linked to elevated oxidative stress that activates inflammation, eventually causing the death of the cell. The advantages of lowering glomerular inflammation lie in the impact upon the cardiovascular system that is lowering the overall chance of developing vascular stiffness and hypertension.
CBD also attenuates cisplatin-induced nephrotoxicity by reducing inflammation, oxidative/nitrosative stress, and cell death.
Helps To Relieve Pain
Cannabinoid receptors are present in the entire body, with the first type – CB1 being very dense in the pain pathways of the spine, brain, and nerves. The second type – CB2 – is more vital for the immune system though is also involved in inflammation. By acting gently on both pathways, CBD and our internal cannabinoids can balance pain as well as inflammation. Besides, CBD also plays a part in the perception of pain and inflammation by activating the TRPV-1 receptor. CBD also subdues inflammatory and neuropathic pain by targeting α3 glycine receptors.
Assists In Reducing Blood Pressure
CBD displays the potential to restrict the damage to the glomeruli by lowering blood pressure. The study discovered that CBD reveals the potential to make blood vessels vasodilate. This, subsequently, enhances the flow of blood while lowering blood pressure. This is extremely important as it improves blood flow and decrease of kidney damage.
Conclusion On CBD For Glomerulonephritis
CBD has greater advantages in treating kidney related issues in comparison to various organic prescriptions. It helps to relieve the patient of pain and other symptoms linked to diseases such as glomerulonephritis. Thereby, CBD can aid a patient cope with their therapy while enjoying life as there is less pain.